Dietary Management of Labrador Retrievers with Subclinical Hepatic Copper Accumulation

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Dietary Management of Labrador Retrievers with Subclinical Hepatic Copper Accumulation

BACKGROUND Genetic and environmental factors, including dietary copper intake, contribute to the pathogenesis of copper-associated hepatitis in Labrador retrievers. Clinical disease is preceded by a subclinical phase in which copper accumulates in the liver. OBJECTIVE To investigate the effect of a low-copper, high-zinc diet on hepatic copper concentration in Labrador retrievers with increase...

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This study summarizes the clinical and pathologic findings in 15 Labrador Retrievers with copper-associated chronic hepatitis (CACH). Our hypothesis was that this form of hepatitis is caused by a defect in hepatic copper metabolism, which most likely originates from a genetic defect. Affected Labradors consisted of 11 female and 4 male Labrador Retrievers. Eight family members of 2 of these pat...

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ژورنال

عنوان ژورنال: Journal of Veterinary Internal Medicine

سال: 2015

ISSN: 0891-6640

DOI: 10.1111/jvim.12574